Effect of Topically Applied Sodium Fusidate Loaded-Silver Nanoparticles as Gel Dosage Form on Burn-Induced Model in Rats

Authors

  • Omar Saleh Abdulkader Department of Pharmacology, Basrah University College of Science and Technology, Basra, Iraq
  • Abdulkareem Hameed Abd Department of Pharmacology, College of Medicine, Al‑Nahrain University, Baghdad, Iraq
  • Ahmed Najim Abood Department of Pharmaceutics, College of Pharmacy, University of Basra, Basra, Iraq

Keywords:

Sodium Fusidate, Silver Nanoparticles, Gel, Topical,

Abstract

Aim: Creating and analyzing a new formulation of sodium fusidate loaded-silver nanoparticles in
the form of a gel. Procedure: sodium fusidate loaded-silver nanoparticles prepared by chemical
reduction method using trisodium citrate as the reducing agent to produce silver nanoparticles
firstly. Then the gel prepared by using carbomer 940 and triethanolamine. sodium fusidate loaded
silver nanoparticles was characterized by globular diameter, polydispersity index (PDI) and pH.
Results: The novel formula had (668.2±0.2nm) globular diameter, normal homogeneous
dispersion (PDI, 0.567±0.002) and pH (6.2±0.05). Conclusions: To our knowledge, this is the first
sodium fusidate loaded-silver nanoparticles nano‑drug delivery system. It has promising
pre‑clinical and clinical uses.

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Published

2024-08-03

Issue

Vol. 3 No. 1 (2024): Medical Journal of Ahl al-Bayt University

Section

Articles